SCR-LIP-000006 · Claim · machine-readable JSON →

For ultrasound diagnosis of lower-limb lipedema, subcutaneous thickness cutoffs of >11.7 mm (pre-tibial), >17.9 mm (anterior thigh), >8.4 mm (lateral leg) and >7.0 mm (medial supramalleolar) provide reproducible reference values.

Emerging diagnostic Evidence certainty: low (GRADE)

Evidence over time

DOI:10.1177/02683555211002340 — supporting · cross sectional · n=89 · 2021 · risk of bias: moderate
Youden/ROC cutoffs; later reused by Vargas 2025 and Foureaux 2025

Populationadult women evaluated for lipedema

Conditionlipedema

Exposurehigh-frequency ultrasound

Comparatorclinically diagnosed lipedema

Outcomereference cutoff values

Scopelower limbs, four points

Derived from a single Brazilian cohort; no prospective multicenter validation.