SCR-LIP-000014 · Claim · machine-readable JSON →

Lipedema occurs in men with the classical phenotype (bilateral, symmetrical, foot-sparing lower-limb fat accumulation, negative Stemmer sign), although it almost exclusively affects women and male occurrence is rare.

Emerging clinical association Evidence certainty: low (GRADE)

Evidence over time

DOI:10.7759/cureus.87332 — supporting · case series · n=5 · 2025 · risk of bias: high
5 men 31-58y; classical phenotype; no histopathology
DOI:10.1590/1677-5449.202301832 — supporting · consensus · n=113 · 2025 · risk of bias: moderate
'occurrence in men is rare' (4.23)

Populationmen diagnosed with lipedema at a referral center

Conditionlipedema

Exposuremale sex

Comparatorclassical female presentation

Outcomeclassical phenotype in men

Scopelipedema in men

Small retrospective series without histopathology; true male prevalence uncertain.