SCR-LIP-000014 · Claim · machine-readable JSON →
Lipedema occurs in men with the classical phenotype (bilateral, symmetrical, foot-sparing lower-limb fat accumulation, negative Stemmer sign), although it almost exclusively affects women and male occurrence is rare.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 2 source(s) · by Amato
- Answers
- 1 question(s)
- Dates
- 2026-05-30 → 2026-06-12
Structured evidence, machine-compiled — not a verdict.
Evidence over time
Evidence (2)
- Lipedema in Men: A Retrospective Case Series of Five Patients From a Brazilian Referral Center — Amato et al. (2025) ✓ verified — consistent · case series · n=5 · 2025 · risk of bias: high · reading confidence: high
“Prevalência estimada de lipedema masculino ~0,2% mundial”
5 men 31-58y; classical phenotype; no histopathology - Brazilian Consensus Statement on Lipedema using the Delphi methodology — Amato et al. (2025) ✓ verified — contextual · consensus · n=113 · 2025 · risk of bias: moderate · reading confidence: high
“afirmação 'prevalência de lipedema no Brasil é 12,3% da população feminina adulta' obteve concordância 3,78/5, inclusão 3,81/5, clareza 3,98/5 e evidência 3,49/5 — menor nível de concordância entre as afirmações aceitas”
'occurrence in men is rare' (4.23)
Context (PECO)
Answers these questions
Gaps & caveats
Small retrospective series without histopathology; true male prevalence uncertain.
Change log
- 2026-05-30 — created
- 2026-06-12 — stance corrected · R-AI-14 audit: evidence stance supporting→context (adopted from independent verifier).
- 2026-06-12 — disputed evidence reviewed · Human review: synthesis — this source supports the claim's direction; the specific(s) it lacks are present in a sibling source (per-claim integrity clean). Accepted.