SCR-LIP-000021 · Claim · machine-readable JSON →

Lipedema and fibromyalgia frequently co-occur: a cross-sectional study found lipedema in 50% of women meeting ACR fibromyalgia criteria, with longer fibromyalgia diagnostic delay and younger menarche as risk factors.

Emerging clinical association Evidence certainty: low (GRADE)

Evidence over time

DOI:10.1177/02683555251321042 — supporting · cross sectional · n=100 · 2025 · risk of bias: moderate
Gunaydin; lipedema in 50%; pain correlated with widespread pain r=0.62

Populationadult women with fibromyalgia (ACR 2016, n=100)

Conditionlipedema

Exposurefibromyalgia

Comparatorfibromyalgia patients without lipedema

Outcomelipedema prevalence and risk factors

Scopeprevalence within a fibromyalgia population

Single-center, no non-FM control; directionality unclear; not Amato-authored.