SCR-LIP-000023 · Claim · machine-readable JSON →

Women with clinically diagnosed lipedema show a higher prevalence of the celiac-associated HLA-DQ2/DQ8 haplotypes than the general population (any HLA 61.1% vs 53.7%; both haplotypes 7.4% vs 1.2%).

Emerging clinical association Evidence certainty: low (GRADE)

Evidence over time

DOI:10.7759/cureus.41594 — supporting · cross sectional · n=95 · 2023 · risk of bias: high
convenience sample; historical comparator (Cecilio 2015)
DOI:10.1590/S0102-67202015000300009 — supporting · cross sectional · n=80 · 2015 · risk of bias: moderate
general-population HLA comparator

Populationadult women with lipedema (Brazil), celiac excluded

Conditionlipedema

Exposurelipedema phenotype

Comparatorgeneral/reference population HLA prevalence

OutcomeHLA-DQ2/DQ8 carrier prevalence

Scopesingle-center cohort, n=95

No concurrent control; selection bias toward symptomatic patients; cannot establish causation.