SCR-LIP-000024 · Claim · machine-readable JSON →

In women with lipedema, food-specific IgG testing shows a paradox: a slightly higher number of positive food reactions despite markedly lower total IgG (1747 vs 2975 AU; p<0.001).

Emerging clinical association Evidence certainty: low (GRADE)

Evidence over time

DOI:10.7759/cureus.93788 — supporting · cross sectional · n=234 · 2025 · risk of bias: high
higher positive count NS (p=0.186); lower total IgG highly significant

Populationadult women with vs without lipedema (Brazil)

Conditionlipedema

Exposurelipedema phenotype

Comparatorwomen without lipedema

Outcomefood-specific IgG positivity and total IgG

Scoperetrospective cross-sectional

IgG subclasses not measured; possible diet/elimination confounding; food-IgG clinical meaning controversial.