SCR-LIP-000024 · Claim · machine-readable JSON →
In women with lipedema, food-specific IgG testing shows a paradox: a slightly higher number of positive food reactions despite markedly lower total IgG (1747 vs 2975 AU; p<0.001).
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s) · by Amato
- Answers
- 1 question(s)
- Dates
- 2026-05-30 → 2026-05-30
Structured evidence, machine-compiled — not a verdict.
Evidence over time
Evidence (1)
- The IgG Paradox in Lipedema: More Food Sensitivities, Less Antibody Production — Amato et al. (2025) ✓ verified — consistent · cross sectional · n=234 · 2025 · risk of bias: high · reading confidence: high
higher positive count NS (p=0.186); lower total IgG highly significant
Context (PECO)
Answers these questions
Gaps & caveats
IgG subclasses not measured; possible diet/elimination confounding; food-IgG clinical meaning controversial.
Change log
- 2026-05-30 — created