SCR-LIP-000025 · Claim · machine-readable JSON →

In a nationally representative NHANES sample, women with serologically confirmed celiac disease had significantly lower gynoid percent fat than non-celiac women (39.5% vs 42.6%; -7.4%; p=0.0007).

Emerging clinical association Evidence certainty: low (GRADE)

Evidence over time

DOI:10.64898/2025.12.01.25341350 — supporting · cross sectional · n=3833 · 2025 · risk of bias: moderate
only 11 celiac cases; ethnic imbalance; cross-sectional
DOI:10.7759/cureus.104222 — supporting · cross sectional · n=3833 · 2026 · risk of bias: moderate
peer-reviewed version, same dataset

PopulationUS women >=20y (NHANES 2011-2014)

Conditionlipedema

Exposureceliac disease autoimmunity

Comparatornon-celiac women

Outcomegynoid percent fat (DXA)

Scopecross-sectional, n=3833 (11 celiac)

Reverse causation partly addressed by BMI strata; n=11 precludes adjustment; DXA proxy not validated against clinical lipedema.