SCR-LIP-000026 · Claim · machine-readable JSON →

The reduced gynoid adiposity associated with celiac disease in NHANES persisted among overweight/obese women (-8.7% overall, p=0.005; -11.3% in obese, p=0.039), arguing against leanness/malnutrition as the sole explanation.

Emerging clinical association Evidence certainty: low (GRADE)

Evidence over time

DOI:10.64898/2025.12.01.25341350 — supporting · cross sectional · n=2503 · 2025 · risk of bias: high
only 7 celiac cases in stratum; estimates unstable

Populationoverweight/obese US women (NHANES)

Conditionlipedema

Exposureceliac disease autoimmunity

Comparatornon-celiac overweight/obese women

Outcomegynoid percent fat, BMI-stratified

Scopecross-sectional sensitivity analysis, n=2503 (7 celiac)

Extremely small cell counts; cannot exclude all reverse causation.