SCR-LIP-000026 · Claim · machine-readable JSON →
The reduced gynoid adiposity associated with celiac disease in NHANES persisted among overweight/obese women (-8.7% overall, p=0.005; -11.3% in obese, p=0.039), arguing against leanness/malnutrition as the sole explanation.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s) · by Amato
- Answers
- 1 question(s)
- Dates
- 2026-05-30 → 2026-05-30
Structured evidence, machine-compiled — not a verdict.
Evidence over time
Evidence (1)
- The Lipedema Phenotype is Inversely Associated with Celiac Disease Autoimmunity: Testing the Immunological Shield Hypothesis in NHANES — Amato et al. (2025) ✓ verified — consistent · cross sectional · n=2503 · 2025 · risk of bias: high · reading confidence: high
“Mulheres com DC tiveram gordura ginóide significativamente menor: 39,5±3,6% vs 42,6±5,2% (p=0,0007) — redução relativa de 7,4%; gordura de pernas 20,3% menor (9,3 vs 11,7 kg; p<0,0001); LTR 14,1% menor (0,77 vs 0,89; p=0,040)”
only 7 celiac cases in stratum; estimates unstable
Context (PECO)
Answers these questions
Gaps & caveats
Extremely small cell counts; cannot exclude all reverse causation.
Change log
- 2026-05-30 — created