SCR-LIP-000027 · Claim · machine-readable JSON →
In NHANES women, a DXA-defined lipedema-like phenotype (leg-to-trunk fat ratio >90th percentile) was associated with a favorable immunometabolic profile, including 44.2% lower HOMA-IR (p<0.001) and 7.6% lower neutrophil-to-lymphocyte ratio (p=0.012).
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 2 source(s) · by Amato
- Answers
- 1 question(s)
- Dates
- 2026-05-30 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Evidence over time
Evidence (2)
- The Lipedema Phenotype is Inversely Associated with Celiac Disease Autoimmunity: Testing the Immunological Shield Hypothesis in NHANES — Amato et al. (2025) ✓ verified — consistent · cross sectional · n=3833 · 2025 · risk of bias: moderate · reading confidence: high
“HOMA-IR mediano 44,2% menor no fenótipo lipedema (1,35 [IQR 0,95–2,01] vs 2,42 [IQR 1,47–4,30]; p<0,001)”
exploratory; DXA proxy may capture gynoid obesity - Exploring the Immunological Shield Hypothesis: A Population-Based Exploration of Phenotypic Divergence Between Lipedema and Celiac Disease Autoimmunity — Amato et al. (2026) ✓ verified — consistent · cross sectional · 2026 · reading confidence: high
Exploratory cross-sectional population study directly examines whether a peripheral/gynoid (lipedema-like) fat distribution confers metabolic protection, reporting lower HOMA-IR and reduced diabetes prevalence with dose-response; supports t
Context (PECO)
Answers these questions
Gaps & caveats
Phenotype proxy unvalidated against clinical lipedema; possible misclassification; no causal direction.
Change log
- 2026-05-30 — created
- 2026-05-31 — evidence added · corroborated by DOI:10.7759/cureus.104222