SCR-LIP-000027 · Claim · machine-readable JSON →

In NHANES women, a DXA-defined lipedema-like phenotype (leg-to-trunk fat ratio >90th percentile) was associated with a favorable immunometabolic profile, including 44.2% lower HOMA-IR (p<0.001) and 7.6% lower neutrophil-to-lymphocyte ratio (p=0.012).

Emerging clinical association Evidence certainty: low (GRADE)

Evidence over time

DOI:10.64898/2025.12.01.25341350 — supporting · cross sectional · n=3833 · 2025 · risk of bias: moderate
exploratory; DXA proxy may capture gynoid obesity

PopulationUS women >=20y (NHANES)

Conditionlipedema

Exposurelipedema-like phenotype (LTR >90th pct)

Comparatorcontrols (LTR <=90th pct)

OutcomeHOMA-IR, NLR

Scopecross-sectional, n=283 phenotype / 3550 controls

Phenotype proxy unvalidated against clinical lipedema; possible misclassification; no causal direction.