SCR-LIP-000028 · Claim · machine-readable JSON →

In NHANES women aged 20-59, a lipedema-like peripheral fat distribution was inversely associated with cancer prevalence: each 1-SD increase in leg-to-trunk fat ratio was associated with 20% lower adjusted odds of cancer (OR 0.795; 95%CI 0.666-0.948; p=0.011).

Evidence over time

Evidence (1)

• Lipedema-like Phenotype and Cancer Prevalence in US Women: A Cross-Sectional Analysis of NHANES 2011–2014 — Amato et al. (2025) ✓ verified — consistent · cross sectional · n=2818 · 2025 · risk of bias: moderate · reading confidence: high
  “Modelo primário ajustado (efeito total, sem idade como mediadora): cada aumento de 1-DP na LTR associou-se a 20% menor chance de câncer (OR 0,795; IC 95% 0,666–0,948; p=0,011)”
  prevalence/survivorship not incidence; reverse causation possible; E-value 1.83

Context (PECO)

Answers these questions

• Does a lipedema-like (peripheral/gynoid) fat distribution protect against cancer or metabolic disease? consistent

Gaps & caveats

Cross-sectional prevalence not incidence; self-reported; residual confounding; cannot distinguish clinical lipedema from peripheral obesity.

Change log

• 2026-05-30 — created

← All claims