SCR-LIP-000029 · Claim · machine-readable JSON →

The inverse association between lipedema-like peripheral fat distribution and cancer prevalence was most robust in women without obesity (OR 0.67 per 1-SD LTR; 95%CI 0.53-0.85; p=0.0007).

Emerging epidemiologic Evidence certainty: low (GRADE)

Evidence over time

DOI:10.64898/2025.12.02.25341445 — supporting · cross sectional · n=2818 · 2025 · risk of bias: moderate
interaction by obesity NS (p=0.58); E-value 2.34 non-obese

PopulationUS women 20-59 stratified by obesity (NHANES)

Conditionlipedema

Exposureleg-to-trunk fat ratio (per 1-SD)

Comparatorlower LTR within obesity stratum

Outcomecancer prevalence

Scopecross-sectional subgroup, n=2818

Underpowered obesity subgroup; survivorship bias; no incidence data.