SCR-LIP-000029 · Claim · machine-readable JSON →

The inverse association between lipedema-like peripheral fat distribution and cancer prevalence was most robust in women without obesity (OR 0.67 per 1-SD LTR; 95%CI 0.53-0.85; p=0.0007).

Claim at a glance

Structured evidence, machine-compiled — not a verdict.

Evidence over time

Lipedema-like Phenotype and Cancer Prevalence in US Women: A Cross-Sectional Analysis of NHANES 2011–2014 — Amato et al. (2025) ✓ verified — consistent · cross sectional · n=2818 · 2025 · risk of bias: moderate · reading confidence: high
“Modelo primário ajustado (efeito total, sem idade como mediadora): cada aumento de 1-DP na LTR associou-se a 20% menor chance de câncer (OR 0,795; IC 95% 0,666–0,948; p=0,011)”
interaction by obesity NS (p=0.58); E-value 2.34 non-obese

PopulationUS women 20-59 stratified by obesity (NHANES)

Conditionlipedema

Exposureleg-to-trunk fat ratio (per 1-SD)

Comparatorlower LTR within obesity stratum

Outcomecancer prevalence

Scopecross-sectional subgroup, n=2818

Underpowered obesity subgroup; survivorship bias; no incidence data.