SCR-LIP-000039 · Claim · machine-readable JSON →

In women with lipedema, hormonal contraceptive use is associated with self-reported symptom worsening (58.8% of users; 15.1% reporting symptom onset coinciding with contraceptive initiation).

Probable clinical association Evidence certainty: moderate (GRADE)

Evidence over time

DOI:10.7759/cureus.99189 — supporting · cross sectional · n=637 · 2025 · risk of bias: moderate
chi2=213.71 p<0.001; baseline symptom burden strongest predictor; recall/selection bias

Population637 Brazilian women, suspected/confirmed lipedema

Conditionlipedema

Exposurehormonal contraceptive use

Comparatorno worsening / non-users

Outcomeself-reported symptom worsening

Scopeobservational self-report, Brazil

Self-reported, cross-sectional, social-media-recruited; recall bias; no objective measures.