SCR-LIP-000042 · Claim · machine-readable JSON →

Lipedema gluteofemoral adipose tissue displays a dominant M2 macrophage transcriptomic signature with CD163+ macrophage enrichment (2.58-fold by qPCR; 1171 differentially expressed genes), indicating a type-2 immune microenvironment.

Evidence over time

Evidence (1)

• DOI:10.3389/fimmu.2022.1004609 — supporting · basic science · 2022 · risk of bias: moderate
  Wolf et al.; CyTOF + RNA-seq; in vitro functional causality (IPI-549)

Context (PECO)

Answers these questions

• What is known about the inflammation and pain mechanism in lipedema tissue? supporting

Gaps & caveats

Cellular source of IL-4/IL-13 not directly identified; mast-cell- vs hypoxia-driven not resolved.

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