SCR-LIP-000042 · Claim · machine-readable JSON →
Lipedema gluteofemoral adipose tissue displays a dominant M2 macrophage transcriptomic signature with CD163+ macrophage enrichment (2.58-fold by qPCR; 1171 differentially expressed genes), indicating a type-2 immune microenvironment.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Probable
- Evidence certainty
- very low (GRADE)
- Evidence
- 2 source(s)
- Answers
- 1 question(s)
- Dates
- 2026-05-30 → 2026-06-12
Structured evidence, machine-compiled — not a verdict.
Evidence over time
Evidence (2)
- A distinct M2 macrophage infiltrate and transcriptomic profile decisively influence adipocyte differentiation in lipedema — Wolf et al. (2022) ✓ verified — consistent · basic science · 2022 · risk of bias: moderate · reading confidence: high
Wolf et al.; CyTOF + RNA-seq; in vitro functional causality (IPI-549) - Lipedema: A Disease Triggered by M2 Polarized Macrophages? — Grewal et al. (2025) ✓ verified — refining · review · 2025 · reading confidence: high
“marcadores inflamatórios e oxidativos (CRP normal, mas TNFSF14, S100-A12, MDA elevados em estágio 3)”
This comprehensive narrative review directly addresses inflammation and pain mechanisms in lipedema tissue, highlighting the anti-inflammatory M2 macrophage phenotype (rather than classical pro-inflammatory pathways) and vascular permeabili
Context (PECO)
Answers these questions
Gaps & caveats
Cellular source of IL-4/IL-13 not directly identified; mast-cell- vs hypoxia-driven not resolved.
Change log
- 2026-05-30 — created
- 2026-05-31 — corroborated_by_layer1 · DOI:10.3390/biomedicines13030561
- 2026-06-12 — disputed evidence reviewed · Human review: synthesis — this source supports the claim's direction; the specific(s) it lacks are present in a sibling source (per-claim integrity clean). Accepted.