SCR-LIP-000043 · Claim · machine-readable JSON →

Lipedema has a distinctive quantitative sensory testing (QST) signature in the affected limb — isolated lowered pressure pain threshold and raised vibration detection threshold with spared thermal thresholds — yielding high diagnostic accuracy (PVTH-score AUC 0.958).

Emerging diagnostic Evidence certainty: low (GRADE)

Evidence over time

DOI:10.1097/PR9.0000000000001155 — supporting · cross sectional · 2024 · risk of bias: moderate
Dinnendahl/Bertsch; only PPT-down and VDT-up of 13 parameters; pattern in thigh, absent in hand

Populationnon-obese women with lipedema

Conditionlipedema

ExposureDFNS quantitative sensory testing

Comparatorunaffected site / controls

Outcomeselective QST abnormality (PPT-down, VDT-up)

Scopeperipheral sensory phenotype, affected limb

Single study; mechanism of the pattern not established; needs independent replication.