SCR-LIP-000052 · Claim · machine-readable JSON →
The clinical syndrome was consolidated in 1951 when Wold, Hines and Allen reported a large case series (about 119 patients) detailing lipedema's orthostatic edema, pain and strong predominance in women.
Evidence over time
Evidence (1)
- Wold LE, Hines EA Jr, Allen EV. Lipedema of the legs: a syndrome characterized by fat legs and orthostatic edema. Ann Intern Med 1951;34(5):1243-50 — supporting · case series · n=119 · 1951 · risk of bias: high
First large clinical series (~119 patients). Early-MEDLINE; cited bibliographically.
Context (PECO)
Answers these questions
- What are the historical milestones in the description and surgical treatment of lipedema? supporting
Gaps & caveats
Uncontrolled historical case series; predates modern criteria.