SCR-LIP-000127 · Claim · machine-readable JSON →

In 258 women with lipedema, the prevalence of clinical lower limb lymphedema increased progressively with BMI: 6.1% in BMI <30, 51.6% in BMI 30–40, and 77.8% in BMI 40–50 kg/m², with statistically significant differences between groups (p=0.0001).

Emerging clinical association Evidence certainty: moderate (GRADE)

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-sonnet-4.6 · 2026-05-31

Evidence over time

Lipedema and the Evolution to Lymphedema With the Progression of Obesity — Pereira de Godoy et al. (2020) — supporting · cross sectional · 2020
Cross-sectional design with bioimpedance-based lymphedema detection in a reasonably large sample (n=258) demonstrates a dose-response gradient between obesity and lymphedema prevalence in lipedema patients, directly supporting progression f

Conditionlipedema

Scopeauto-ingested from Layer 1 surveillance

Auto-ingested single source; not yet human-reviewed.