SCR-LIP-000157 · Claim · machine-readable JSON →

This systematic review reports familial incidence of lipedema in 15% of first-degree female relatives consistent with X-linked dominant or autosomal dominant inheritance with incomplete penetrance, identifies an AKR1C1 missense variant (a gene involved in progesterone metabolism) as the first mutated gene in a family with primary non-syndromic lipedema, and notes hormonal/progesterone-pathway involvement.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Lipedema Research—Quo Vadis? — Ernst et al. (2023) — supporting · review · 2023
  The review explicitly documents familial inheritance patterns and a hormone-metabolism gene (AKR1C1, progesterone pathway) variant linked to lipedema, directly bearing on the role of heredity and hormones in onset.

Context (PECO)

Answers these questions

• Do hormones and heredity influence the onset of lipedema? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created

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