SCR-LIP-000170 · Claim · machine-readable JSON →
In a survey of 98 Polish women with lipedema, all WHOQOL-BREF domains scored below general-population values (physical health 45.4, psychological 46.3, social relationships 50.4, environment 49.6 on 0-100), 59.2% had PHQ-9 scores >=10 indicating possible depression (mean PHQ-9 12.2), and core lipedema symptoms (Factor 1: leg heaviness, joint/tissue/muscle pain, swelling, stiffness) were the only significant predictor of worse quality of life (beta=-0.345, p=0.004, model explaining 23.5% of variance).
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s)
- Answers
- 3 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Quality of life, its factors, and sociodemographic characteristics of Polish women with lipedema — Dudek et al. (2021) ✓ verified — consistent · cross sectional · 2021 · reading confidence: high
“Todos os domínios abaixo dos valores da população geral. Apenas 34,7% avaliaram QoL geral como boa/muito boa; 20,4% como ruim/muito ruim”
Cross-sectional online survey of women with lipedema directly measuring quality of life (WHOQOL-BREF) and depression (PHQ-9), with multivariate regression linking symptom burden to reduced QoL; directly addresses the question's affirmative [grade capped moderate->low per curated Oxford N4]
Context (PECO)
Answers these questions
- How does lipedema affect quality of life, depression, and anxiety in affected patients? consistent
- How does lipedema affect health-related quality of life? consistent
- How does lipedema affect mental health (depression and anxiety)? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000020