SCR-LIP-000178 · Claim · machine-readable JSON →
In 44 women with lipedema, median total SF-36 quality of life was 57.4/100 (lowest domains: general health 35, pain 47.5, social functioning 50, energy/fatigue 45), below historical healthy Polish population (61.6) and a prior lipedema cohort (59.3), and SF-36 scores did not differ by BMI or WHtR strata.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- low (GRADE)
- Evidence
- 1 source(s)
- Answers
- 2 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Examining the characteristic features of lipedema and the usefulness of BMI and WHtR in clinical evaluation — Czerwińska et al. (2025) ✓ verified — consistent · cross sectional · 2025 · reading confidence: high
“Qualidade de vida: SF-36 total mediano 57,4/100; dimensões — funcionamento físico 80, limitação por saúde física 75, limitação por problemas emocionais 66,6, energia/fadiga 45, bem-estar emocional 60, funcionamento social 50, dor 47,5, saúde geral 35.”
Cross-sectional study reporting SF-36 quality of life in lipedema patients showing reduced scores versus reference populations, directly bearing on the quality-of-life aspect of the question; however it does not assess depression or anxiety
Context (PECO)
Answers these questions
- How does lipedema affect quality of life, depression, and anxiety in affected patients? consistent
- How does lipedema affect health-related quality of life? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000020