SCR-LIP-000178 · Claim · machine-readable JSON →

In 44 women with lipedema, median total SF-36 quality of life was 57.4/100 (lowest domains: general health 35, pain 47.5, social functioning 50, energy/fatigue 45), below historical healthy Polish population (61.6) and a prior lipedema cohort (59.3), and SF-36 scores did not differ by BMI or WHtR strata.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Examining the characteristic features of lipedema and the usefulness of BMI and WHtR in clinical evaluation — Czerwińska et al. (2025) — supporting · cross sectional · 2025
  Cross-sectional study reporting SF-36 quality of life in lipedema patients showing reduced scores versus reference populations, directly bearing on the quality-of-life aspect of the question; however it does not assess depression or anxiety

Context (PECO)

Answers these questions

• How does lipedema affect quality of life, depression, and anxiety in affected patients? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000020

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