SCR-LIP-000188 · Claim · machine-readable JSON →

A simplified 9-item self-applied screening questionnaire (derived from the validated QuASiL) based on clinical diagnostic criteria (post-pubertal women, bilateral symmetric fat deposit below the hip sparing feet, negative Stemmer and Godet signs, pain on palpation, spontaneous bruising) achieved diagnostic discrimination of AUC=0.912 for an individual 7-question predictive model and AUC=0.8615 for a total-score model against expert clinical diagnosis in 109 women (59 with lipedema, 50 without), with the item 'feeling something wrong in the legs' being most discriminative (OR=4.328).

Claim at a glance

Structured evidence, machine-compiled — not a verdict.

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Criação de questionário e modelo de rastreamento de lipedema — Amato et al. (2020) ✓ verified — refining · cross sectional · 2020 · reading confidence: high
“aumentando o nível de suspeição clínica em uma doença historicamente subdiagnosticada”
The article develops and validates a screening tool grounded in standard clinical diagnostic criteria for lipedema and reports diagnostic accuracy (AUC) against expert clinical reference, directly bearing on diagnostic criteria and their re [grade capped moderate->low per curated Oxford N4]

Populationwomen with and without lipedema (n=109)

Conditionlipedema

Exposure9-item self-applied screening questionnaire (QuASiL-derived)

Comparatorexpert clinical diagnosis

Outcomediagnostic discrimination (AUC, OR)

Scopeauto-ingested from Layer 1 surveillance

Auto-ingested single source; not yet human-reviewed.