SCR-LIP-000190 · Claim · machine-readable JSON →

In a prospective cohort of 138 lipedema and 111 lymphedema patients, a CART algorithm using three clinical variables—bruising, body disproportion, and non-swollen feet (cuffing sign)—classified patients with 100% accuracy; lipedema was characterized by symmetry (100%), spared feet (93.5%), pain (92%), bruising (90.6%), telangiectasias (89.9%), and family history (84.7%), and staged 1-4 (stage I 37.7%, II 34.8%, III 22.5%, IV 5.1%).

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Building evidence for diagnosis of lipedema: using a classification and regression tree (CART) algorithm to differentiate lipedema from lymphedema patients — FORNER-CORDERO et al. (2025) — supporting · cohort · 2025
  The article directly addresses clinical diagnostic criteria and the stage classification system (stages 1-4) used in lipedema, and quantifies the discriminative reliability of clinical features via a validated CART model, bearing directly o

Context (PECO)

Answers these questions

• What clinical criteria and stage/type classification systems are used to diagnose and grade lipedema, and how reliable are they? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000022

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