SCR-LIP-000197 · Claim · machine-readable JSON →
In this systematic review of lipedema assessment tools, DXA fat-mass distribution indices (arm+leg FM/total FM) achieved an AUC of 0.91 (95% CI 0.87–0.94) and pretibial subcutaneous thickness on ultrasound achieved excellent AUC (cutoffs 11.6–11.8 mm; sensitivity 0.77–0.79, specificity 0.92–0.96) for diagnosing lipedema, while MRI, NCMRL, ICG lymphography, and lymphoscintigraphy were used mainly for differential diagnosis though with highly variable protocols and only fair-to-slight inter-radiologist agreement for MRI/NCMRL (Kappa 0.14–0.34).
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Assessment Tools to Quantify the Physical Aspects of Lipedema: A Systematic Review — Eason et al. (2025) — supporting · review · 2025
The systematic review directly catalogs DXA, MRI, lymphoscintigraphy and other imaging tools used to quantify and differentiate lipedema, reporting diagnostic performance (DXA and ultrasound AUCs) and noting imaging modalities are used for
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000023