SCR-LIP-000215 · Claim · machine-readable JSON →

Family-based exome sequencing of 31 individuals from 9 lipedema families identified candidate variants in 469 genes with no single gene shared across all families, supporting genetic heterogeneity rather than a Mendelian single-gene cause, with gene ontology enrichment in vasopressin receptor activity (AVPR1A, AVPR2), microfibril binding (FBN, ELN, LTBP), and patched binding (PTCH1/2, Hedgehog pathway).

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• A Family-Based Study of Inherited Genetic Risk in Lipedema — Morgan et al. (2024) — refines · case series · 2024
  The article directly addresses the question by reporting specific candidate genes/pathways and inheritance patterns; it refines the affirmative by concluding lipedema shows polygenic heterogeneity rather than a single Mendelian variant.

Context (PECO)

Answers these questions

• What specific genetic variants or inheritance patterns have been identified in lipedema? refines

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000025

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