SCR-LIP-000224 · Claim · machine-readable JSON →
In a rigorously defined UK lipedema cohort (n=130), onset was frequently associated with hormonal changes (puberty, pregnancy, menopause), and the first dedicated GWAS identified a suggestive genetic locus (rs1409440, OR_meta 2.01, P_meta 4×10⁻⁶) upstream of LHFPL6, replicated in an independent 100,000 Genomes cohort.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- moderate (GRADE)
- Evidence
- 2 source(s)
- Answers
- 3 question(s)
- Dates
- 2026-05-31 → 2026-06-12
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (2)
- Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort — Grigoriadis et al. (2022) ✓ verified — consistent · cohort · 2022 · reading confidence: high
“Início frequentemente associado a mudanças hormonais (puberdade, gestação, menopausa)”
The lipedema article directly reports hormonal triggers of onset and a heritable genetic association (GWAS locus near LHFPL6 with independent replication), supporting both hormonal and hereditary influence, though the genetic signal was onl - Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort — Grigoriadis et al. (2021) ✓ verified — consistent · cross sectional · 2021 · reading confidence: high
“Top SNPs included loci associated with lipoma formation, biosynthesis of hormones and lipid hydroxylation.”
The GWAS found only suggestive (not genome-wide significant) loci involving hormone biosynthesis and lipid pathways, plus noted frequent family history, consistent with hereditary and hormonal influences; findings require replication, lower
Context (PECO)
Answers these questions
- Do hormones and heredity influence the onset of lipedema? consistent
- Do hormonal factors (puberty, pregnancy, menopause, estrogen) trigger or influence lipedema onset? consistent
- Is lipedema onset influenced by heredity and family history? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000012
- 2026-05-31 — evidence added · corroborated by DOI:10.1101/2021.06.15.21258988
- 2026-06-12 — disputed evidence reviewed · Human review: rs1409440/OR/P/LHFPL6 are this UK GWAS's own findings, present in the full text but not the truncated abstract. Accepted.