SCR-LIP-000227 · Claim · machine-readable JSON →
Family-based DNA sequencing of 31 individuals from 9 lipedema families identified candidate variants in 469 genes with no single Mendelian causative gene, supporting polygenic genetic heterogeneity (consistent with positive family history in 60-80% of cases), with enrichment in vasopressin receptor activity (AVPR1A, AVPR2), microfibril binding, and patched binding gene ontology categories.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- A Family-Based Study of Inherited Genetic Risk in Lipedema — Morgan et al. (2024) — supporting · case series · 2024
Largest family-based sequencing study in lipedema documents heredity (positive family history 60-80%, polygenic risk) and points to hormone-related pathways (vasopressin receptor activity linked to HPA axis), directly bearing on the questio
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000012