SCR-LIP-000236 · Claim · machine-readable JSON →

A GWAS of a UK lipedema cohort (n=130) identified a suggestive association (not genome-wide significant) at SNP rs1409440 (OR_meta 2.01; P_meta 4×10⁻⁶) located upstream of LHFPL6, a gene involved in lipoma formation, with additional support from an independent 100,000 Genomes replication cohort.

Claim at a glance

Structured evidence, machine-compiled — not a verdict.

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort — Grigoriadis et al. (2022) ✓ verified — consistent · cross sectional · 2022 · reading confidence: high
“SNP top: rs1409440 (OR_meta 2,01; P_meta 4 × 10⁻⁶) — significância sugestiva (não genome-wide significativa, P<5×10⁻⁸), localizado upstream de LHFPL6 (Lipoma HMGIC Fusion Partner-Like 6)”
Article reports a dedicated GWAS identifying a specific genetic locus (rs1409440 near LHFPL6) associated with lipedema, directly addressing the question; association is only suggestive due to small sample size.

Populationwomen with lipedema (UK cohort, n=130)

Conditionlipedema

ExposureSNP rs1409440 upstream of LHFPL6

Comparatorpopulation controls (100,000 Genomes replication)

Outcomesuggestive GWAS association (OR 2.01, P=4×10⁻⁶)

Scopeauto-ingested from Layer 1 surveillance

Auto-ingested single source; not yet human-reviewed.