SCR-LIP-000236 · Claim · machine-readable JSON →
A GWAS of a UK lipedema cohort (n=130) identified a suggestive association (not genome-wide significant) at SNP rs1409440 (OR_meta 2.01; P_meta 4×10⁻⁶) located upstream of LHFPL6, a gene involved in lipoma formation, with additional support from an independent 100,000 Genomes replication cohort.
Created: 2026-05-31 · Last updated: 2026-05-31
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort — Grigoriadis et al. (2022) — supporting · cross sectional · 2022
Article reports a dedicated GWAS identifying a specific genetic locus (rs1409440 near LHFPL6) associated with lipedema, directly addressing the question; association is only suggestive due to small sample size.
Context (PECO)
Answers these questions
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000025