SCR-LIP-000238 · Claim · machine-readable JSON →
This systematic review reports that lipedema most likely follows autosomal dominant inheritance with incomplete penetrance and sex limitation (positive family history in up to 64% of women), identifies no confirmed gene for primary non-syndromic lipedema, and catalogs syndromic associations (POU1F1A c.196C>T p.Pro24Leu; NSD1 p.Cys2175Ser/Sotos; 7q11.23 deletion/Williams-Beuren with ELN, FZD9, MLXIPL; ABCC6/PXE; ALDH18A1/cutis laxa III) plus 17 GWAS/animal-model candidate genes (e.g., LYPLAL1, TBX15, HOXC13, RSPO3, VEGFA, PROX1, VEGFR3, PRDM16).
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- very low (GRADE)
- Evidence
- 1 source(s)
- Answers
- 3 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Genetics of lipedema: new perspectives on genetic research and molecular diagnoses — Paolacci S et al. (2019) ✓ verified — consistent · review · 2019 · reading confidence: high
“herança autossômica dominante com penetrância incompleta e limitação sexual (principalmente mulheres afetadas) = modo mais provável de herança. História familiar positiva autorrelatada em até 64% das mulheres”
The article directly addresses the question by reviewing inheritance patterns and specific genetic variants/candidate genes in lipedema, including the proposed autosomal dominant mode and named syndromic mutations and GWAS candidates. [grade capped moderate->very_low per curated Oxford N6]
Context (PECO)
Answers these questions
- Do hormones and heredity influence the onset of lipedema? consistent
- What specific genetic variants or inheritance patterns have been identified in lipedema? consistent
- Is lipedema onset influenced by heredity and family history? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-06-02 — merged · absorbed duplicate SCR-LIP-000228 (same paper/finding)
- 2026-05-31 — created · auto-ingested for SQ-LIP-000025