SCR-LIP-000239 · Claim · machine-readable JSON →

This narrative review reports that lipedema follows a female-preferential autosomal dominant inheritance pattern and is associated with altered expression of specific genes including CCND1, ZNF423, CYP19A1 (aromatase), COL6A3, and MMP14, while noting that genetic studies remain underpowered.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• Lipedema: Insights into Morphology, Pathophysiology, and Challenges — Poojari et al. (2022) — supporting · review · 2022
  The review explicitly discusses genetic implications, citing autosomal dominant female-preferential inheritance and specific genes (CCND1, ZNF423, CYP19A1, COL6A3, MMP14), directly addressing the question, though as a narrative synthesis wi

Context (PECO)

Answers these questions

• What specific genetic variants or inheritance patterns have been identified in lipedema? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000025

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