SCR-LIP-000268 · Claim · machine-readable JSON →

In a prospective cohort of 138 lipedema patients (median age 47.6 years), 85% reported a positive family history, 57% had symptom onset related to puberty (median onset age 14.8 years), and Type III (ankle-to-hip) involvement predominated at ~71%, with a median diagnostic delay exceeding 25 years.

Claim at a glance

Structured evidence, machine-compiled — not a verdict.

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

PREVALENCE OF CLINICAL MANIFESTATIONS AND ORTHOPEDIC ALTERATIONS IN PATIENTS WITH LIPEDEMA: A PROSPECTIVE COHORT STUDY — Forner-Cordero et al. (2021) ✓ verified — consistent · cohort · 2021 · reading confidence: high
“História familiar em 85% das pacientes (média 1,1 parentes de 1º grau e 1,3 de 2º grau) Início relacionado à puberdade em 57% — janela hormonal estrogênica confirmada como gatilho prevalente”
The article reports demographic and onset characteristics of a lipedema patient cohort, including age, familial prevalence, pubertal onset, and diagnostic delay, which directly inform who lipedema affects and its patterns of occurrence.

Populationlipedema patients, prospective cohort (n=138)

Conditionlipedema

Exposureclinical and demographic characteristics at diagnosis

Outcomefamily history, onset age, type distribution, diagnostic delay

Scopeauto-ingested from Layer 1 surveillance

Auto-ingested single source; not yet human-reviewed.