SCR-LIP-000268 · Claim · machine-readable JSON →

In a prospective cohort of 138 lipedema patients (median age 47.6 years), 85% reported a positive family history, 57% had symptom onset related to puberty (median onset age 14.8 years), and Type III (ankle-to-hip) involvement predominated at ~71%, with a median diagnostic delay exceeding 25 years.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.2458/lymph.4838 — supporting · cohort · 2021
  The article reports demographic and onset characteristics of a lipedema patient cohort, including age, familial prevalence, pubertal onset, and diagnostic delay, which directly inform who lipedema affects and its patterns of occurrence.

Context (PECO)

Answers these questions

• How common is lipedema, and who does it affect? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000002

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