SCR-LIP-000277 · Claim · machine-readable JSON →

In non-obese lipedema patients, standardized QST (DFNS protocol) revealed selective alterations in only 2 of 13 parameters at the affected lateral thigh—elevated pressure pain (PPT, AUC 0.9075) and reduced vibration detection (VDT, AUC 0.8638)—and a combined PPT+VDT z-score score was proposed as a rapid diagnostic test for lipedema.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1101/2023.04.25.23289086 — supporting · cross sectional · 2023
  Cross-sectional case-control comparison proposing a quantitative sensory testing-based diagnostic score (PVTH-score) with high discriminative accuracy, directly addressing the development of a screening/diagnostic tool for identifying liped

Context (PECO)

Answers these questions

• Is lipedema underdiagnosed, and can screening tools help identify it? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000004

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