SCR-LIP-000299 · Claim · machine-readable JSON →

Quantitative sensory testing in non-obese women with lipedema showed a 2-fold reduced pressure pain threshold and 2.5-fold increased vibration detection threshold selectively in the affected thigh (quadriceps/patella) but not the hand, with no central alterations, suggesting a peripheral pain mechanism via ECM stiffness and mechanoceptive amplification.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1111/obr.13953 — refines · review · 2025
  The narrative review reports localized pain phenotype (reduced pressure pain threshold) in lipedema via QST, indicating a peripheral pain mechanism, but does not address fibromyalgia or systemic chronic-pain comorbidity; the cited QST findi

Context (PECO)

Answers these questions

• Is lipedema associated with fibromyalgia and other chronic-pain conditions? refines

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000008

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