SCR-LIP-000351 · Claim · machine-readable JSON →

In a systematic review and meta-analysis of cross-sectional cohorts, women with lipedema showed reduced HRQoL across all SF-36/RAND-36 domains versus population norms, with the largest deficits in energy/fatigue (43.50 vs 59.4), bodily pain (51.77 vs 77.4), role physical (51.10 vs 82.4), and general health (49.64 vs 73.1), plus impaired emotional well-being (64.19 vs 73.2) reflecting frequent anxiety/depression.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1177/02683555251410009 — supporting · meta analysis · 2025
  Meta-analysis directly quantifying HRQoL and psychosocial impacts in lipedema patients with pooled effect sizes; high heterogeneity (I²=83–93%) lowers confidence.

Context (PECO)

Answers these questions

• How does lipedema affect quality of life, depression, and anxiety in affected patients? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000020

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