SCR-LIP-000351 · Claim · machine-readable JSON →
In a systematic review and meta-analysis of cross-sectional cohorts, women with lipedema showed reduced HRQoL across all SF-36/RAND-36 domains versus population norms, with the largest deficits in energy/fatigue (43.50 vs 59.4), bodily pain (51.77 vs 77.4), role physical (51.10 vs 82.4), and general health (49.64 vs 73.1), plus impaired emotional well-being (64.19 vs 73.2) reflecting frequent anxiety/depression.
Claim at a glance
- Type
- clinical association
- Knowledge state
- Emerging
- Evidence certainty
- moderate (GRADE)
- Evidence
- 1 source(s)
- Answers
- 3 question(s)
- Dates
- 2026-05-31 → 2026-05-31
Structured evidence, machine-compiled — not a verdict.
Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31
Evidence over time
Evidence (1)
- Health-related quality of life among lipedema patients: A systematic review and meta-analysis — Günay et al. (2025) ✓ verified — consistent · meta analysis · 2025 · reading confidence: high
“Emotional well-being: 64,19 (IC 95% 59,86–68,52) vs norma 73,2 — ansiedade/depressão frequentes; I²=89,41%”
Meta-analysis directly quantifying HRQoL and psychosocial impacts in lipedema patients with pooled effect sizes; high heterogeneity (I²=83–93%) lowers confidence.
Context (PECO)
Answers these questions
- How does lipedema affect quality of life, depression, and anxiety in affected patients? consistent
- How does lipedema affect health-related quality of life? consistent
- How does lipedema affect mental health (depression and anxiety)? consistent
Gaps & caveats
Auto-ingested single source; not yet human-reviewed.
Change log
- 2026-05-31 — created · auto-ingested for SQ-LIP-000020