SCR-LIP-000382 · Claim · machine-readable JSON →

MR lymphangiography with intracutaneous gadoteridol distinguished pure lipedema from lipo-lymphedema: epifascial high-signal edema on T2-TSE was present in 100% (16/16) of lipo-lymphedema limbs but 0% (0/10) of pure lipedema limbs, while subcutaneous fat was thickened in all 26 limbs; contrast peak in lower-leg lymphatics was delayed in lipo-lymphedema (peak 45–55 min) versus lipedema (peak 35 min), and 60% of pure lipedema limbs showed subclinical dilated lymphatics despite no T2 lymphedema signal.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.1016/j.mvr.2009.01.005 — supporting · case series · 2009
  The study directly evaluates MR lymphangiography to distinguish lipedema from lipo-lymphedema, reporting specific imaging findings, signal differences, and lymphatic flow timing that differentiate the conditions, directly bearing on the que

Context (PECO)

Answers these questions

• Can MRI, lymphoscintigraphy, or DXA differentiate lipedema from lymphedema and other fat distributions? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000023

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