SCR-LIP-000104 · Claim · machine-readable JSON →

In a cross-sectional survey of 354 women with lipedema, 35% (124/354) met ACR 2016 diagnostic criteria for fibromyalgia syndrome, and those with fibromyalgia had significantly higher anxiety, depression, and impaired quality of life compared to those without.

Emerging clinical association Evidence certainty: moderate (GRADE)

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-sonnet-4.6 · 2026-05-31

Evidence over time

Prevalence of Fibromyalgia Syndrome in Women with Lipedema and Its Effect on Anxiety, Depression, and Quality of Life — Cagliyan Turk et al. (2024) — supporting · cross sectional · 2024
The study directly measures fibromyalgia prevalence in a lipedema population using validated diagnostic criteria (ACR 2016), finding a 35% comorbidity rate. Limitations include self-reported data via online survey and potential selection bi
Common and Contrasting Characteristics of the Chronic Soft-Tissue Pain Conditions Fibromyalgia and Lipedema — Angst et al. (2021) — supporting · cross sectional · 2021
Direct empirical comparison of fibromyalgia and lipedema cohorts with validated instruments; cross-sectional design limits causal inference, but the 34% comorbidity rate and phenotypic overlap data directly address the association between l

Conditionlipedema

Scopeauto-ingested from Layer 1 surveillance

Auto-ingested single source; not yet human-reviewed.