SCR-LIP-000214 · Claim · machine-readable JSON →

In a case-control study using TaqMan genotyping, carriers of the IL-6 rs1800795 (-174G/C) G allele (CG+GG) had a 5.92-fold higher risk of lipedema versus non-carriers (CC) (OR=5.92, 95%CI 1.983–17.711, p<0.001), with samples in Hardy-Weinberg equilibrium.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.26355/eurrev_202003_20690 — supporting · case control · 2020
  The article directly investigates a specific genetic variant (IL-6 rs1800795) in lipedema and reports an association (OR=5.92) with the G allele, directly addressing the question on genetic variants. Single small case-control study without

Context (PECO)

Answers these questions

• What specific genetic variants or inheritance patterns have been identified in lipedema? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000025

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