SCR-LIP-000290 · Claim · machine-readable JSON →

In a comparative observational study, 39.6% (21/53) of lipedema patients met ACR 2016 criteria for fibromyalgia, and the comorbid lipedema+fibromyalgia subgroup had significantly higher pain (median VAS 60 vs 27 for lipedema alone, p<0.001) and worse SF-36 quality-of-life scores across all 8 domains.

Created: 2026-05-31 · Last updated: 2026-05-31

Auto-compiled by the Layer 1 surveillance loop; not yet human-reviewed. anthropic/claude-opus-4.8 · 2026-05-31

Evidence over time

Evidence (1)

• DOI:10.47582/jompac.1301253 — supporting · cross sectional · 2023
  The study directly quantifies the co-occurrence of fibromyalgia in lipedema patients (39.6% met ACR 2016 criteria) and characterizes pain/QoL effects, with results converging with prior studies (34%, 50%). It is observational and unadjusted

Context (PECO)

Answers these questions

• Is lipedema associated with fibromyalgia and other chronic-pain conditions? supporting

Gaps & caveats

Auto-ingested single source; not yet human-reviewed.

Change log

• 2026-05-31 — created · auto-ingested for SQ-LIP-000008

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